ea0065pl5 | Society for Endocrinology International Medal Lecture | SFEBES2019
Cone Roger
, Sweeney Patrick
, Gimenez Luis
, Hernandez Ciria
The central melanocortin circuitry is at the heart of the adipostat, and functions as a bidirectional switch on the control of energy storage. The circuitry is composed of the anorexigenic arcuate POMC neurons, and the orexigenic arcuate AgRP neurons, and their melanocortin-3 (MC3R) and melanocortin-4 (MC4R) target neurons, found in key neuroendocrine, behavioral, and autonomic control sites throughout the brain. Mutations in the MC4R, present at a composite allele frequency a...